MME ELISA Kit for Human(Homo sapiens) | EIAab.comMME ELISA Kit for Human(Homo sapiens)

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Index > Protein center > MME(Gene name) > Human

MME (Gene name),

Neprilysin (Protein name ), NEP_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

MME(EPN);

Protein name:

Neprilysin;

Alternative:

Common acute lymphocytic leukemia antigen(CALLA);Atriopeptidase;Neutral endopeptidase 24.11(NEP;Neutral endopeptidase);Enkephalinase;Skin fibroblast elastase(SFE);

CD:

CD10;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Function:

Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers.

Subcellular Location:

Cell membrane Single-pass type II membrane protein

Protein Attributes:

Sequence length:

750

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P08473

STRING:

9606.ENSP00000353679

SMR:

P08473

UniGene:

Hs.307734

KEGG:

hsa:4311

MIM:

120520

Pfam:

PF01431

Uniprot:

P08473

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ELISA Kit for Human Neprilysin

Cat.:

E1785h

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Manual:

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Packing:

96T

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ELISA Kit for Human Neprilysin

Cat.:

E1785r

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Manual:

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96T

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ELISA Kit for Human Neprilysin

MSDS:

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ELISA Kit for Human Neprilysin

MSDS:

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ELISA Kit for Human Neprilysin

Cat.:

E1785m

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Packing:

96T

CLIA Kit for Human Neprilysin

Cat.:

U1785m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Neprilysin

MSDS:

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CLIA Kit for Human Neprilysin

Cat.:

U1785r

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human Neprilysin

MSDS:

Please sign in first.

CLIA Kit for Human Neprilysin

Cat.:

U1785h

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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Polyclonal Antibody for Human Neprilysin

Cat.:

P1785Rb-r

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Neprilysin

Cat.:

P1785Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Neprilysin

Cat.:

P1785Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Neprilysin

Monoclonal Antibody for Human Neprilysin

Protein for Human Neprilysin

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Common acute lymphocytic leukemia antigen is identical to neutral endopeptidase."
Letarte M. , Vera S. , Tran R. , Addis J.B.L. , Onizuka R.J. , Quackenbush E.J. , Jongeneel C.V. , McInnes R.R.
J. Exp. Med.168:1247-1253(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Kidney.
2.

"Molecular cloning of the common acute lymphoblastic leukemia antigen (CALLA) identifies a type II integral membrane protein."
Shipp M.A. , Richardson N.E. , Sayre P.H. , Brown N.R. , Masteller E.L. , Clayton L.K. , Ritz J. , Reinherz E.L.
Proc. Natl. Acad. Sci. U.S.A.85:4819-4823(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"Organization of the gene encoding common acute lymphoblastic leukemia antigen (neutral endopeptidase 24.11): multiple miniexons and separate 5' untranslated regions."
D'Adamio L. , Shipp M.A. , Masteller E.L. , Reinherz E.L.
Proc. Natl. Acad. Sci. U.S.A.86:7103-7107(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Placenta.
5.

NHLBI resequencing and genotyping service (RS&G)
Submitted (2007-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
6.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
8.

"Molecular cloning and amino acid sequence of human enkephalinase (neutral endopeptidase)."
Malfroy B. , Kuang W.-J. , Seeburg P.H. , Mason A.J. , Schofield P.R.
FEBS Lett.229:206-210(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-750
tissue: Placenta.
9.

"Endopeptidase-24.11 in human plasma degrades atrial natriuretic factor (ANF) to ANF(99-105/106-126)."
Yandle T.G. , Brennan S.O. , Espiner E.A. , Nicholls M.G. , Richards A.M.
Peptides10:891-894(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN THE DEGRADATION OF ANF
10.

"Asp650 is crucial for catalytic activity of neutral endopeptidase 24-11."
Le Moual H. , Dion N. , Roques B.P. , Crine P. , Boileau G.
Eur. J. Biochem.221:475-480(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACTIVE SITE ASP-651
11.

"Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
Zhang H. , Li X.-J. , Martin D.B. , Aebersold R.
Nat. Biotechnol.21:660-666(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-145 AND ASN-285
12.

"Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism."
Rice G.I. , Thomas D.A. , Grant P.J. , Turner A.J. , Hooper N.M.
Biochem. J.383:45-51(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ANGIOTENSIN PEPTIDE METABOLISM;BIOPHYSICOCHEMICAL PROPERTIES
13.

"Human opiorphin, a natural antinociceptive modulator of opioid-dependent pathways."
Wisner A. , Dufour E. , Messaoudi M. , Nejdi A. , Marcel A. , Ungeheuer M.-N. , Rougeot C.
Proc. Natl. Acad. Sci. U.S.A.103:17979-17984(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INHIBITION BY OPIORPHIN
14.

"Neprilysin is identical to skin fibroblast elastase: its role in skin aging and UV responses."
Morisaki N. , Moriwaki S. , Sugiyama-Nakagiri Y. , Haketa K. , Takema Y. , Imokawa G.
J. Biol. Chem.285:39819-39827(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION AS SKIN FIBROBLAST ELASTASE;FUNCTION
15.

"Neutral endopeptidase is a myristoylated protein."
Zheng R. , Horiguchi A. , Iida K. , Lee J. , Shen R. , Goodman O.B. Jr. , Nanus D.M.
Mol. Cell. Biochem.335:173-180(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MYRISTOYLATION AT GLY-2
16.

"The human CD10 lacking an N-glycan at Asn(628) is deficient in surface expression and neutral endopeptidase activity."
Sato B. , Katagiri Y.U. , Iijima K. , Yamada H. , Ito S. , Kawasaki N. , Okita H. , Fujimoto J. , Kiyokawa N.
Biochim. Biophys. Acta1820:1715-1723(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-628
17.

"Structure of human neutral endopeptidase (Neprilysin) complexed with phosphoramidon."
Oefner C. , D'Arcy A. , Hennig M. , Winkler F.K. , Dale G.E.
J. Mol. Biol.296:341-349(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS);GLYCOSYLATION AT ASN-145; ASN-325 AND ASN-628
18.

"Structural analysis of neprilysin with various specific and potent inhibitors."
Oefner C. , Roques B.P. , Fournie-Zaluski M.-C. , Dale G.E.
Acta Crystallogr. D60:392-396(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 55-750 IN COMPLEXES WITH ZINC IONS AND SYNTHETIC INHIBITORS;DISULFIDE BONDS;COFACTOR;GLYCOSYLATION AT ASN-145; ASN-325 AND ASN-628
19.

"Structural studies of a bifunctional inhibitor of neprilysin and DPP-IV."
Oefner C. , Pierau S. , Schulz H. , Dale G.E.
Acta Crystallogr. D63:975-981(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 55-750 IN COMPLEX WITH ZINC IONS AND THE SYNTHETIC INHIBITOR MCB3937;DISULFIDE BONDS;COFACTOR;GLYCOSYLATION AT ASN-145; ASN-325 AND ASN-628

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